Laser Diffraction
Mastersizer 3000 – HYDRO SV (Malvern) uses the technique of laser diffraction to measure particle size distribution.
Specifications
- Particle size range from 0.1 – 1000 µm
- Suitable for crystals, suspensions, emulsions, and granules
- Software controlled magnetic stirrer for dispersion control
- Wash station provided for quick and easy cleaning
Representative Publications
Devos, C., Brozzi, E., Van Gerven, T. & Kuhn, S. (2023) Characterization of a modular microfluidic section for seeded nucleation in multiphase flow. Org. Process Res. Dev. 27, 311–321.
Fatemi, N., Devos, C., Van Gerven, T. & Kuhn, S. (2022) Continuous crystallization of paracetamol exploiting gas-liquid flow in modular nucleation and growth stages. Chem. Eng. Sci. 248, 117095.
Dynamic Light Scattering (DLS)
The Litesizer 500 (Anton Paar) can determine the particle size, zeta potential, molecular mass, refractive index and transmittance on a wide variety of samples. It gives rapid and accurate insight into particle systems.
Specifications
- Size measuring range: 0.3 nm to 10 µm
- Zeta potential measuring range: > ±1000 mV
- Measurement angles: 15°, 90°, 175°
- Suitable for nanoparticles, emulsions, and biopharmaceutical formulations
- Temperature-controlled measurements for stability testing
Crystal 16
The Crystal 16 platform (Technobis) can be used to study nucleation, growth, and dissolution kinetics under precisely controlled temperature cycles. By monitoring the turbidity of the 16 parallel vials, solubility curves and metastable zone widths (MSZW) can be determined.
Specifications
- Parallel screening in 16 temperature-controlled vials
- Real-time turbidity monitoring to detect clear and cloud points
- Determination of solubility curves, induction times and MSZWs
Representative Publications
Devos, C., Van Gerven, T. & Kuhn, S. (2021) Nucleation kinetics for homogeneous, heterogeneous, seeded and ultrasound-induced paracetamol crystallization.
CrystEngComm 23, 5164–5175. (https://doi.org/10.1039/d1ce00676b)
Devos, C., Van Gerven, T. & Kuhn, S. (2021) A Review of Experimental Methods for Nucleation Rate Determination in Large-Volume Batch and Microfluidic Crystallization.
Cryst. Growth Des. 21, 2541–2565. (https://doi.org/10.1021/acs.cgd.0c01606)
